Novel Influenza A H1N1 Update

h1n1update

Centers for Disease Control and Prevention

  • Ted Cieslak COL MC USA, Department of Defense Liaison Officer
  • 50 pages
  • For Official Use Only
  • Sensitive But Unclassified
  • September 22, 2009

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Pandemic Influenza in the Past

  • Past Pandemics
  • 1918 (H1N1)
  • 40-50 million deaths, 500K in US
  • 1957 (H2N2)
  • 2 million deaths, 70K in US
  • 1968 (H3N2)
  • 1-4 million deaths, 34K in US

U.S. Military Laboratory-Based Influenza Surveillance

  • Sentinel Site Surveillance
  • Through USAFSAM, Brooks City Base TX
  • Hospital & Clinic-Based
  • Recruit Training Surveillance
  • Through NHRC, San Diego CA
  • Overseas Surveillance
  • Through NAMRUs, other labs

Response to H1N1
• Strategic National Stockpile
• Distributed 25% pro rata supply
• Enhanced Surveillance Initiated
• PCR panH1N1 kits for testing
• Development at CDC, EUA at FDA, manufacture at ATCC, and ready to ship in ~ 2.5 weeks
• Distributed Kits, so far:
• Domestic: 95 labs
• DOD: 15 labs
• International: >250 labs in 140 countries
• Virus Characterization
• >1000 genes sequenced from >260 viruses
• Submitted to GenBank

H1N1 “Current” Status

  • Lab-Confirmed Cases
  • 44,317 total cases when reporting stopped in July
  • 8,842 hospitalized
  • 555 deaths
  • Represents approximately 3 M cases
  • Overall activity has declined since schools closed, but focal areas of activity have increased
  • Viruses in US and Internationally show no evidence of significant genetic/antigenic change

h1n1

h1n12h1n13

  • Disease likely persists through summer in US, possible surge in late August when school returns
  • Monitor closely for genetic and antigenic virus changes
  • Expected higher attack rate (20-30%) than in spring (6-15%), notably affecting younger individuals
  • Vaccine availability possibly mid October, Federal funds for distribution and administration are available
  • Healthcare facility support in part from HPP grants
  • SNS Antiviral stocks likely to be distributed
  • Drifted H3N2 may co-circulate with novel H1N1

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